Microdosing GLP-1's (Ozempic and Mounjaro)
- Thrive Collective

- Mar 11
- 3 min read
Updated: Jul 17

You've likely heard of Ozempic and Mounjaro for managing type 2 diabetes and aiding weight loss. But what if smaller doses of these powerful medications could unlock broader health benefits with fewer side effects? Welcome to the intriguing world of microdosing GLP-1 receptor agonists.
Understanding GLP-1: Your Body's Natural Regulator
At its core, GLP-1 (Glucagon-Like Peptide-1) is a natural hormone released after you eat. It's a master regulator, working behind the scenes to:
Boost insulin: Helping your body lower blood sugar.
Curb glucagon: Preventing your liver from releasing too much sugar.
Slow digestion: Making you feel fuller, longer, which helps with appetite control.
Medications like Ozempic (semaglutide) and Mounjaro (tirzepatide) are designed to mimic these crucial actions. While initially approved for type 2 diabetes, their effectiveness in weight loss and improving overall metabolic health has been a game-changer.
Now, imagine harnessing these benefits with even smaller doses. That's the promise of microdosing: using lower-than-standard amounts to potentially achieve therapeutic effects while significantly reducing common side effects.
The Potential Advantages of Microdosing Ozempic & Mounjaro
Why are so many people, and even some healthcare professionals, exploring this approach? The potential benefits are compelling:
Enhanced Metabolic Health: These medications can improve insulin sensitivity, stabilize blood sugar, and reduce stubborn visceral fat. This can be a powerful defense against conditions like type 2 diabetes, fatty liver disease, and heart disease.
Appetite Regulation & Weight Management: Even at lower doses, GLP-1 agonists can help quiet "food noise" – those constant thoughts about food – and reduce cravings. This makes it easier to stick to a balanced diet, supporting sustainable weight loss and maintenance.
Reduced Side Effects: Standard doses can sometimes come with gastrointestinal discomfort like nausea or constipation. Microdosing may significantly lessen these bothersome side effects, making the treatment more tolerable for many.
Cost-Effectiveness: Smaller doses mean less medication used, which can translate to lower costs, potentially making these powerful treatments more accessible.
Beyond Weight Loss: Broader Health Applications
The benefits of microdosing might extend far beyond traditional uses:
Polycystic Ovary Syndrome (PCOS): A key issue in PCOS is insulin resistance. By improving insulin sensitivity, these medications can help alleviate symptoms like weight gain, irregular periods, and excess androgen production (which contributes to acne and unwanted hair growth).
Acne & Skin Health: For those whose breakouts are linked to insulin resistance, regulating insulin levels and reducing systemic inflammation through microdosing could lead to clearer skin.
Insulin Resistance & Brain Fog: If you experience brain fog and cognitive sluggishness, insulin resistance could be a culprit. Improving insulin sensitivity can support clearer thinking, better focus, and overall cognitive function.
Crohn’s Disease & Inflammatory Conditions: Emerging research suggests GLP-1 agonists may help reduce gut inflammation. Their ability to modulate immune responses and improve gut barrier function offers a promising avenue for managing chronic inflammatory conditions.
Insights from Dr. Tyna Moore: A Holistic Perspective
Dr. Tyna Moore, a renowned naturopathic and chiropractic physician specialising in holistic regenerative medicine, recently shared her perspectives on microdosing GLP-1 receptor agonists on 'The Diary of a CEO' podcast. Her key takeaways underscore the potential:
Gut Microbiome Transformation: Dr. Moore highlighted the positive impact Ozempic can have on the gut microbiome, which is vital for overall health and metabolic function.
Individualized Dosing: She strongly emphasized that dosing should be tailored to the individual, suggesting that many might be on higher doses than necessary, leading to avoidable side effects.
Personal Experience: In a powerful testament, Dr. Moore shared how microdosing "saved her mother's life," illustrating the profound impact this approach can have in real-world clinical practice.
Important Considerations & Cautions
While the possibilities of microdosing are exciting, it's crucial to approach this practice with informed caution:
Lack of Extensive Research: While early findings and anecdotal reports are promising, more comprehensive, long-term research is needed to fully understand the efficacy and safety of microdosing for off-label uses.
Individual Variability: Your body's response to microdosing can differ greatly from someone else's. What works for one person may not work for you.
Medical Supervision is Paramount: Never embark on any medication regimen, especially microdosing, without the explicit guidance and supervision of a qualified healthcare professional. They can assess your individual health needs, monitor potential risks, and ensure the safest and most effective outcomes.
The Future of Personalised Medicine?
Microdosing Ozempic and Mounjaro opens up fascinating new avenues for enhancing metabolic health, managing weight, and potentially improving overall well-being. Insights from experts like Dr. Tyna Moore offer a glimpse into a future where personalised dosing could revolutionise how we approach these powerful medications.
However, remember that your health is unique. Before considering microdosing, have an in-depth conversation with your doctor to determine if this approach is safe and appropriate for your specific health goals.
For a deeper understanding of Dr. Tyna Moore's perspectives on microdosing Ozempic, you can listen to her full discussion on 'The Diary of a CEO' podcast:




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